Casa Gisira is a few steps away from Piazza Duomo, the centre of Catania.
There are several international companies flying to Catania's Fontanarossa airport.
You can then reach the apartment by taxi or by car (car rental is available at the airport) or by bus (Alibus N. 457 stops in Piazza Alcalà, proceed on foot to via Gisira), or from the train station using taxi or buses (numbers: 123, 431, 723, 981).