The closest large airport is Rome's Fiumicino. There is also the small international airport (served by RyanAir) of Perugia/Assisi (now San Francesco). It is about 25 minutes away.

TRAIN: It is easy to take a train from the airport. You will need to transfer in Rome for a train to Assisi. Or, you can pick up a rental car at Perugia or Foligno.

CAR: Most guests rent a car and drive to me.
Head in the direction of Rome and the road will turn into the GRA (Grande Raccordo Anulare), which is a ring road around Rome. You are looking for the A1 to Firenze (Florence). Exit at uscita 10, but 8, 9, and 10 all have the same exit. Keep heading for Firenze / A1 and get a ticket. This much should have taken you about 40 minutes.
Once on the A1 you drive for about 25 minutes and exit at ORTE. Go to the lane with the picture of someone handing the driver something and your life will be easier. (Toll is 3.80euro) Once out the gate go to your right and follow the signs for Perugia.
You will be heading basically east for about 20 minutes before you see the signs for Perugia. Follow signs to Perugia/Cesena and you will end up on the E45. Stay on the E45 for about 40 minutes more and exit at PONTE NUOVO (right after DERUTA). (You will notice the sign for Deruta Nord lists BETTONA but the next exit is a little closer.
Come off the exit ramp and go to your right, then go over the bridge. After the bridge, the road will make a sharp right but you want to make a left onto the little street between the bar and the brick church. You’ll be on this road for a couple kilometers until you come to a T-stop. Go right toward Bettona. Almost there. Follow this a few kilometers. Pass through Signoria until you see the hill of Bettona with its church towers. The road will bend to the left (at Colle) and you will want to go straight up the hill and, after lots of bends in the road, you eventually will come to the town. Follow the walls around to the left until you see the front gate.
Once inside the gate, take the road on the left and come up to the main piazza — its one way only. You will see a large church on the left, the bar and our town museum on the right, the bank, post office, fountain and another church on the other side of the piazza. Go right and pass through the piazza, down the only street you can go. I'm in the next little piazza on the left- Piazza Preziotti, number 4.
If you get lost ask for Michael and they’ll tell you where I live.