By PLANE: flight to the Falcone Borsellino airport of Palermo, the Vincenzo Florio airport of Trapani or Catania Fontanarossa airport. So, by bus or by car. It takes about two hours to get to Agrigento By BUS: there are regular connections between the main towns in Sicily and Agrigento. The routes are operated by several companies so you have to check the times with the carriers on a case by case basis. There is also a bus service runs regularly between Agrigento with Rome, Naples and Salerno. By TRAIN: Agrigento is connected to Palermo and Caltanissetta (from where the branches off line for Catania-Siracusa, Messina and the Continent. The Central Station is located in the city center.