Two main options:

1) Fly to regional airport - Sant' Egidio Umbria (15 minute drive from villa - pick up can be arranged) The airport has daily flights from Milan.
NEW DIRECT CONNECTION :
RyanAir
Flies from London Stansted to PERUGIA Ancona, Bologna Forli and Rome Ciampino; from London Luton to Rome Ciampino. Also flies from Dublin, East Midlands, Glasgow and Liverpool to Rome Ciampino and from Bournemouth, Doncaster, Dublin, Glasglow, and Liverpool To Pisa.

2) Fly to Rome international airport - Fiumicino. From there the train journey to Perugia is 2.5 hrs. Pickup from the railway station can be arranged. A car can be hired from the airport - the drive is approx 1.5 hrs.