From Rome and Cesena: E45, exit Pontefelcino Perugia-Ponte Rio, Ponte Rio here turn right to S. Marino and after 3 km you will be the goal.
Coming from the A1 towards Florence, exit Val di Chiana, follow the highway up to Perugia, exit at Perugia-S. Faustino direction Railway Station and from there proceed to S. Marco and then S. Marino.
From Perugia you can easily visit some of the most beautiful cities in Italy - Assisi, Gubbio, Lake Trasimeno, Spello, Todi, Spoleto, Deruta, just to name a few - parks, lakes, fountains and waterfalls, picturesque villages, a holiday very special, not to mention the cuisine and fine wines: Umbria will remain in your heart forever!