You can get to Kefalonia Island either by plane or car.
There are direct flights from UK and other EU countries.
Villa Brio is 30 min drive from island's International Airport.
In case you use a car, you take the ferry from Italy to Patra (mainland Greece).
Then you take the ferry to Sami (island's main port), about 3 hours trip.
Villa Brio is 35 min drive from Sami port.
Another option is to take the ferry from Killini (1 hour drive from Patra) to Poros port, which is just 10 min drive to Villa Brio.